OP443 Evaluating The Value Of Endovascular Innovations For Aortic Valve Replacement Through Clinical Benefits, Patient-reported Outcomes And Resource Consumption.

Introduction The use of most recent Transcatheter aortic valve implants (TAVI) in the treatment symptomatic severe stenosis (SAS) is evolving with expanded indications from inoperable/high-risk to intermediate and low risk patients. Consequently, TAVI outcomes must be monitored highlight its value under real-world conditions. Our aim was prospectively evaluate (SAPIEN 3) terms patient's health-related quality life (HRQoL), clinical outcomes, healthcare resource utilization (HRU). Methods An observational prospective study including all consecutive patients SAS undergoing a transcatheter implantation Edwards SAPIEN 3 (transfemoral access) conducted full accordance guidelines European Society Cardiology. Patients were evaluated before intervention (baseline), at discharge, after one, six twelve months implant. A thoughtful systematic evaluation patients’ HRQoL (EQ-5D 5L, Short Form-36 Health Survey -SF-36- Kansas City Cardiomyopathy Questionnaire -KCCQ-), endpoints (that is, cardiovascular mortality, rates stroke, major bleeding, myocardial infarction, re-hospitalization), echocardiographic measurements, HRU Length stay-LOS- ward/intensive care unit -ICU-) implemented. Multivariate regression models applied test while controlling key factors patient’ severity baseline). Results total seventy-six (fifty percent female, fifty-five intermediate-high risk) mean age 82.1 ± 4.78 years included. Implant success 97.34% death 2.6% one year. Significant reductions maximum gradients achieved maintained during follow-up. Mean LOS ward (5.2 4.0days) ICU (0.22 0.64 days) low. Statistically significant improvements detected KCCQ overall summary scores, EQ-5D, SF-36 (Physical component summary) - adjusted p < 0.05 intervention. Conclusions represents safe effective innovation for benefits translated into HRQoL. Besides, provides new insights health-economic modelling optimization limited resources special importance current pandemic situation.